Electroosmotic flow analysis of a branched U-turn nanofluidic device

Electroosmotic Flow in Nanofluidic Channels

We report the measurement of electroosmotic mobilities in nanofluidic channels with rectangular cross sections and compare our results with theory. Nanofluidic channels were milled directly into borosilicate glass between two closely spaced microchannels with a focused ion beam instrument, and the nanochannels had half-depths (h) of 27, 54, and 108 nm and the same half-width of 265 nm. We measu...

Fabrication and electroosmotic flow measurements in micro- and nanofluidic channels

An easy method for fabricating microand nanofluidic channels, entirely made of a thermally grown silicon dioxide is presented. The nanochannels are up to 1-mm long and have widths and heights down to 200 nm, whereas the microfluidic channels are 20-lm wide and 4.8-lm high. The nanochannels are created at the interface of two silicon wafers. Their fabrication is based on the expansion of growing...

Concentration gradient focusing and separation in a silica nanofluidic channel with a non-uniform electroosmotic flow.

The simultaneous concentration gradient focusing and separation of proteins in a silica nanofluidic channel of various geometries is investigated experimentally and theoretically. Previous modelling of a similar device [Inglis et al., Angew. Chem. Int. Ed., 2011, 50, 7546] assumed a uniform velocity profile along the length of the nanochannel. Using detailed numerical analysis incorporating cha...

Autoantibodies make a U-turn

Like the immune response itself, our efforts to understand the "rules" for self-nonself discrimination are constantly evolving. The discovery of pattern recognition receptors-the Toll-like receptor (TLR) family in particular-shifted the emphasis of self-nonself recognition from lymphocytes functioning in the adaptive immune system to antigen-presenting cells (APCs) functioning in the innate imm...

Supporting Information for Concentration Gradient Focusing and Separation in a Silica Nanofluidic Channel with a Non-uniform Electroosmotic Flow